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In CBA mice, long-term administration of Epitalon preserved brain and liver mitochondrial ultrastructure, even after irradiation, suggesting real structural protection at the organ level [45]

Intrinsic and extrinsic negative regulators of nuclear protein transport processes

Increased mitochondrial biogenesis (stimulates PGC-1 activation through stimulation of NO by guanylate cyclase) (144) and changes the muscle fiber type to a more oxidative phenotype when combined with the SIT [through the role of nuclear factor activated T cells (NFAT)calcineurin] (145147)

Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4