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Se-dependent enzymes include DIO1, which is expressed in the kidneys and liver, and DIO2, present in the brain and brown adipose tissue, among other organs [27]

The environment, lifestyle, and the resulting OS can also induce epigenetic variations, post-translational modifications of histones, coding and non-coding RNAs, and DNA methylation, which are closely linked to spermiogenesis alteration and male infertility [18]