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Through extensive analysis of a wide spectrum of diseases captured in CKB, smoking was found to be associated with increased risks of 56 diseases and 22 causes of death ( Lancet Public Health 2022) , including cancer ( Cancer 2015) , chronic respiratory and cardiovascular diseases ( Lancet 2015) , diabetes ( Lancet Public Health 2018) , and many other under-studied conditions

Here we describe the protocol of a randomized controlled trial investigating the effect of the plain packaging of cigarettes on smoking behavior in a real-world setting