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An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations

The tumor suppressor p53 directly binds to G6PD and prevents formation of the active G6PD dimer whereas the mutant p53 fails to inhibit G6PD in cancer cells (64)