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In certain investigations, GHRH-like compounds and GHS-R activators were associated with apparent increases in pulsatile growth hormone secretion20-fold and 47-fold above baseline, respectively

PMID: 9705830 by Kelner M.J., et al

Thus, based on the obtained information from these questionnaires and clinical analyses, we characterized our LC patients

The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity