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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

In addition to IL-4, several other cytokines, including TNF-, IL-1, IL-6, and IL-8, contribute to CD (163)

Some of the most common PCBs include phthalates, brominated flame retardants, and perfluorinated chemicals