african artist 1993 1997 painting ecosystem destruction cigarette Liso Pemba | Xhosa woman smoking a pipe (2010) Gerard Sekoto (1913 - 1993)

Tobacco products have claimed the lives of many consumers, but when laced with faster-acting toxins their potential for getting away with murder is clear: the victims administer the poison themselves as the evidence goes up in smoke

Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

While it is not the only component in cigarette smoke responsible for throat discomfort, its effects on circulation and tissue recovery can contribute to ongoing, constant irritation

The bottom line Cannabis is a popular drug, but it is associated with harmful health effects