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Acknowledgements We thank Pierre-Georges Meister for the conditioning of the medication and Philippe Maeder for his helpful comments throughout this study

The activation of the AGE-RAGE axis amplifies chronic inflammation and oxidative stress in both microenvironments, while SNS overactivity and elevated catecholamines induce vasoconstriction in both testicular and penile vasculature, forming a vicious cycle of sympathetic activation and inflammatory damage (207)