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These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

Outcome measures cover wet muscle weight recovery, isometric and isotonic force generation, histological assessment of regenerated fibers, and immunohistochemistry for myogenic markers like MyoD and myogenin

Its best to see a clinician to rule out inflammatory arthritis, too

Mike brings more than just a medical perspective to his clients