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Disclosure of interest: Raffaele Ornello reports compensations from Novartis and Allergan, Teva Pharmaceutical Industries, Eli Lilly and Company

The danger of paracetamol overdose is that early symptoms such as nausea, vomiting, sweating, or mild abdominal discomfort may be minimal or delayed

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Many different conditions affect the contents of intracellular GSH, some of them are the presence of heavy metals, high glucose concentrations, protein malnutrition, thermal shock, exposure to reactive oxygen and nitrogen species including, H 2 O 2 and nitric oxide, ozone exposure, ionizing radiation, and cigarette smoke [37,40,61,73,81]