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The Panel used the IC/BPS definition agreed upon by the Society for Urodynamics and Female Urology (SUFU): "An unpleasant sensation (pain, pressure, discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than six weeks duration, in the absence of infection or other identifiable causes. 2 This definition was selected because it allows treatment to begin after a relatively short symptomatic period, preventing treatment withholding that could occur with definitions that require longer symptom durations (i.e., six months)

We subsequently determined whether IPA enhances ISC proliferation in organoid assays, determining that no differences in colonic organoid formation and development were present between Veh- and IPA-treated mice at D0, indicating that IPA does not affect ISC proliferation ex vivo in the absence of DSS-induced injury

[DOI] [PubMed] [Google Scholar] 3.Meredith TJ, Vale JA

J Neuroinflammation 2:234247