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35, 36 Adding to the controversy, a multi-center phase IIb RCT found that avoidance of arterial hyperoxemia versus usual care failed to demonstrate differences in AKI incidence or severity in patients undergoing cardiac surgery

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(6) The research team hypothesized that AOD 9604 possibly enhanced the doxorubicin binding to multiple breast cancer cell protein targets, thereby exhibiting greater anti-proliferative activity against the MCF-7 breast cancer cell line compared to chitosan loaded with doxorubicin alone