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Primary sites: Abdomen (avoiding 2 inches around the navel) Outer thighs Back of upper arms Upper buttocks Rotation pattern example: Day 1: Left abdomen Day 2: Right abdomen Day 3: Left thigh Day 4: Right thigh Day 5: Left arm Day 6: Right arm Day 7: Return to left abdomen Keep at least one inch between injection sites in the same general area

Food intake Satiety May affect responsiveness to leptin (preclinical only) Discover More Its proposed human mechanism is extrapolated from animal models

Setmelanotide was proven effective for weight loss in these genetically defined populations and is generally well tolerated 39

If you inject on Monday, inject every Monday