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Several changes in structural (reduced tendon CSA and fibril diameter), cellular (decreased cell proliferation and stem/progenitor cell quantity), and mechanical properties (reduced modulus and strength), beyond just alterations to AGE-mediated crosslinks, occur in tendon during the aging process and have been recently reviewed in detail (Svensson et al ., 2016)

dilution 1:50) and a biotinylated goat anti-mouse IgG antibody to identify proliferating cells

Moreover, the complexity of the cell composition of this tissue and the elevated oxygen levels corroborate to elevated capacity of the CNS in ROS production

The collection of studies published on ferroptosis in stroke to date have provided a comprehensive and informative overview of the field