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Second, mitochondrial damage disrupts the redox balance of NAD + /NADH (93)

Several amino acids not only serve as intermediates for the tricarboxylic acid cycle in mitochondria but also function as instructive signals that shape immune cell function 70

For example, SLC38A5 has been implicated in gemcitabine resistance by reducing lipid ROS through the regulation of GSH levels and the mTOR-SREBP1 signaling pathway