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WES identified oxidative stress-related mutational signatures, including SBS3, SBS5 and SBS18, which are enriched in smoking-related non-small cell lung cancers 20,25,26

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Smoke contains many highly reactive chemicals like benzene, acrylonitrile, nicotine, hydrogen cyanide, formaldehyde, ammonia, arsenic, carbon monoxide, and several other toxins which are adsorbed and condensate on the inner wall of the lungs in to a sticky brown mass, called tar

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