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[51] E-liquids usually contain propylene glycol, glycerin, nicotine, flavorings, additives, and differing amounts of contaminants

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Not necessarily, but chain-vaping high-strength salt nicotine (like 50mg) can lead to nicotine tolerance and physical symptoms such as dizziness, nausea, or insomnia

The per-protocol analysis was of interest, given our aim of assessing the actual effect of a policy to introduce a maximum size of cigarette packs rather than just asking people to smoke from smaller packs