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However, further studies are needed to elucidate the underlying mechanisms by which trained immunity contributes to disease activity and to determine whether inhibition of trained immunity can prevent disease exacerbation

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Other vitamins and minerals that have powerful antioxidant properties include vitamin A, vitamin E, manganese and selenium

Upon incidence of exaggerated ER stress, overactivation of UPR occur, which stimulates PERK, via liberation of GRP78, resulting in promotion in the pro-apoptotic factor, CHOP that instigates apoptotic cascades and hampers Bcl-2 (Romine and Wiseman 2019)