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Potential Side Effects of GLP-1 Medications: Gastrointestinal discomfort including constipation, diarrhea, nausea, and indigestion Loss of bone density and/or strength, loss of muscle mass and energy Inadequate nutrition intake from foods Key Considerations for GLP-1 Therapy Support: Bone Health: Ensure adequate Calcium, Magnesium, Vitamin K, and Vitamin D intake to maintain strong and healthy bones.* Muscle Mass: Prevent muscle loss by adding Protein, Amino Acids and other exercise support supplements into your routine.* Energy Levels: Low energy levels may occur during GLP-1 therapy

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Nevertheless, whether 15-LOX participates in the maintenance of skin homeostasis by triggering ferroptosis through lipid peroxidation remains to be further explored (Figure 2)