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2021), which are very different from other cell death modes, including apoptosis, necrosis, and autophagy (Jin et al

In addition to 2D cell culture, 3D organoid systems or co-culture systems with stromal fibroblasts, immune cells or endothelial cells have increased translational relevance by modelling the tumour microenvironment, heterotypic signalling and drug penetration kinetics (219, 220)

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