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Safety and Monitoring : Given the potential risks, especially related to tumor growth due to increased angiogenesis, it is crucial to monitor health metrics and use the minimum effective dose

The viability of human dermal fibroblasts varies depending on the peptide used The cytotoxicity of the tested peptides was determined in primary human dermal fibroblasts (HDF) with the Alamar blue assay

Pericytes also react to cytokines and triggers the release of proinflammatory molecules, which leads to BBB breakdown in vitro and induces activation of a proinflammatory state of astrocytes, endothelial cells, and microglia, the brains innate immune cell [31]

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