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The induced-fit docking successfully reproduced the authentic pose of galantamine (Supplementary Figure S10), yielding an RMSD value of 0.93 between the predicted and actual poses

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This amplifies gut-to-brain signaling and increases the brains sensitivity to gastrointestinal sensations ( The bloodbrain barrier around the area postrema, is more porous thus allowing it to act as a chemosensory trigger zone for nausea and vomiting ( Unfortunately, beyond the specific GLP-1 pathways, multi-agonist therapies do not bypass the gastrointestinal adverse events despite broader receptor targeting

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