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doi: 10.1186/s12967-019-1821-7 79 PieczenikS

However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials

This leads to mitochondrial metabolic disorders, affecting ATP production, activating kinases to produce O 2 - , triggering oxidative stress, and further damaging mitochondria [204]

A bunch of studies from 2012 "confirms the ability of copper peptides to improve aging skin conditions, which make them indispensable in anti-aging and protective cosmetic products." Several research theories suggest that "bioactive peptides hold great potential for cancer therapy and diagnostics." Thereby indicating that peptides are safe for topical use