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They are undertreated because trial populations have historically skewed male

The rise in systolic blood pressure results from a 1 mediated increase in heart rate and ventricular contractility The rise in diastolic pressure results from stimulation of 1 and 2 receptor mediated vasoconstriction in many vascular beds Epinephrine also stimulates 2 receptors present in skeletal muscle blood vessels, resulting in their dilation at low doses, at which 2 receptor stimulation predominates over receptor stimulation, total peripheral resistance and diastolic pressure may fall FDA Indications: Figure 1