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HUBERMAN: The typical therapeutic doses that are prescribed are anywhere from 300 to 500 micrograms subcutaneously, maybe two or three times per week

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developed a novel sustained-release formulation, an intra-articular injectable dexamethasone-loaded thermosensitive hydrogel using a chitosan-glycerin-borax matrix to alleviate inflammation and pain [43]

Using a 29 to 31 gauge needle, allowing the solution to reach room temperature, and injecting slowly all minimize discomfort