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In the case of tobacco, inefficient metabolism of nitrogen by the plant can lead to high concentrations of some nitrogen-based compounds in the leaf, the presence of which lead to the formation of certain tobacco-specific toxicants in smoke

Origin and History of the First Cigarette Pack The history of cigarette packs takes us back to the rise of the tobacco industry in the late 19th century

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6 The prevalence of non-functional and deletion CYP2A6 alleles in Asian populations, among whom the reported lung cancer risk for smokers is much lower than it is for Whites, has led to the hypothesis that lower levels of CYP2A6-catalyzed nicotine metabolism (resulting in the presence of more nicotine) causes decreased smoking dose and intensity and therefore decreased carcinogen exposure and lung cancer risk