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while 7 of the 12 patients reported subjective pain relief exceeding six months, the complete absence of a placebo control group or standardized pain-scale methodology severely limits the scientific validity and reproducibility of the findings

The SDF-1/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1

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Moreover, DAG extracted from Sargentodoxa cuneate exerts its antioxidant effect by upregulating GPX4 expression and downregulating phosphoextracellular regulated protein kinases and HO-1 expression to counteract APAP-induced ferroptosis in hepatocytes (Liu et al., 2022)