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10.1016/j.cell.2021.09.002 75 ManfordA

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showed that the extent of PAGs inhibitory activity toward CSE, with cysteine as the substrate, depends on the preincubation time of the inhibitor with the enzyme as well as on the concentration of cysteine (Yadav et al., 2019)

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This biphasic dose-response demonstrates that "more is not better" there is an optimal concentration window for copper peptide efficacy

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