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385 SSK1-loaded neurotransmitter-derived lipid nanoparticles, as novel nanomedicines, can penetrate the permeability of the blood-brain barrier, eliminate senescent cells, reduce the deposition of -amyloid, and improve the cognitive function of aged AD mice

Lack of TDP-43 leads to perturbed transcriptome in axon and dendrites and dysregulated transcripts code for genes that are key component of mRNA translation, cytoskeleton, and mitochondria mediated energy production and metabolism 35