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In animals, aerosol exposure was found to increase secretion of inflammatory markers, induced airway hyper-reactivity and caused lung tissue degradation in chronic exposure. But in 2018, Public Health England, Englands public health agency, reiterated its claim that vaping is at least 95% safer than smoking

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[86] Epigenetic studies support this link, showing that ACSF3 is differentially methylated in smoke-exposed fetal lungs, and an integrative study identified it as a key regulator of COPD

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