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Research goals: Longevity & Anti-Aging, Metabolic & Weight Description 5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that converts nicotinamide and S-adenosyl-l-methionine (SAM) into 1-methylnicotinamide and S-adenosyl-l-homocysteine

Consequently, it is important to understand how the microbiome responds to NNMTi-focused obesity treatments

However, absorption decreases significantly as doses increase, and individuals with compromised gut health may absorb only 1-2%

Pharmacy Compounding Advisory Committee Briefing Document