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Under UV exposure, ATRA reduces the expression of proteins like E3 ligase Hrd1, sustaining Nrf2 activity and contributing to photoprotection and repair mechanisms essential for melanocytes

All animal procedures conformed to the UK legislation Animals (Scientific Procedures) Act 1986 (United Kingdom) and the University of Oxford Ethical Review Committee policy, with a final ethical review by the Animals in Science Regulation Unit (ASRU) of the UK Home Office

UV exposure while using lightening ingredients is like trying to fill a bucket with holes in the bottom