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F a = (AUC 0t IMDoseIV)/(AUC 0t IVDoseIM) 100%

Injured tissue heals faster when it has an adequate blood supply delivering oxygen and nutrients

The process of spermatogenesis takes approximately 74 days from initial cell division to mature sperm release, meaning therapeutic interventions require sustained treatment periods to show measurable outcomes

Beyond mediating outer mitochondrial membrane fusion, Mfn1/2 participates in mitophagy regulation, mitochondrial cristae remodeling, and facilitates stress-associated unfolded protein response (UPR) (Hu et al., 2019