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Many of the oxidative stress biomarker profiles are altered in ALS bio-samples and animal models, where it has been observed that oxidative stress promotes the aggregation of acetylated TDP-43 which hinders RNA binding and encourages the accumulation of insoluble, hyperphosphorylated TDP-43 species

Iron imunomodulates the termination of the inflammatory response, as elevated Fe level increase the M2 phenotype and reduce the pro-inflammatory M1 response, reducing the IL-12/IL-10 balance

Focusing on drugs with established safety profiles should accelerate translation if we find promising candidates

Clin Ther 28:755760 Rumack BH (2002) Acetaminophen hepatotoxicity: the first 35 years