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It is already known that metal electrodes can promote gliosis, scarring, and prolonged inflammation, but can chronic implantation have any benefit [387]

Safety during pregnancy and breastfeeding hasnt been established

Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth

32-34 Acute toxicities arise from sudden exposures to substantial quantities of some metals (such as from occupational exposure to aluminum dust or breaking a mercury-containing thermometer) and typically affect multiple organ systems, commonly the gastrointestinal tract, cardiovascular system, nervous system, endocrine system, kidneys, hair, and nails