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While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]

According to Su et al.'s (2019) findings, GABA causes H + ATPase activation, decreases Na + uptake, H 2 O 2 -induced K + efflux, and ROS concentration by employing mutants pop 25 and gad 1,2 (with reduced ability of GABA synthesis)

[84] [85] Plants and algae [edit] There is some evidence that bacterial fermentation of plant foods and symbiotic relationships between algae and bacteria can provide vitamin B 12

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