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As NAD + is the precursor of NADH, the low levels of both metabolites suggest NAD + depletion while the NAD + /NADH ratio remained unchanged in most of the diseases (Fig

Redox Biol 11:535542 Davletova S, Rizhsky L, Liang H, Shengqiang Z, Oliver DJ, Coutu J, Shulaev V, Schlauch K, Mittler R (2005) Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis

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Biomarker candidate research is therefore a key avenue to improve diagnosis