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10.1104/pp.104.047357 138 PokoraW.Bacik-RemisiewiczA.TukajS.KalinowskaR.Pawlik-SkowroskaB.DziadziuszkoM.et al

Hormone Optimization & Hormone Replacement Therapy: Traumatic injury to the brain can often result in hormonal imbalances and pituitary dysfunctions that give rise to long-term detrimental effects, particularly with altered blood supply or mechanical shearing effects on hormone-regulating neural pathways in the hypothalamus and pituitary gland

That approach produces the most predictable results

Free fatty acid oxidation generates reactive oxygen species faster than endogenous antioxidant systems can neutralise them