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He said he would, and he took it

The delayed antidepressant effects of SSRIs can be reduced by co-treatment of pindolol, a nonselective beta blocker with 5-HT 1A R antagonist activity ( 1A R partial agonist busipirone which has long been used to treat anxiety also demonstrates clinical efficacy when given in combination with SSRIs ( 1A R partial agonist properties, has been approved for treatment of major depressive disorder in adults ( 1A R antagonists and partial agonists attenuate adverse behavioral responses to antidepressants in adolescents, treatment for teen depression should take into consideration potential drug therapies with 5-HT 1A R antagonist activity to improve antidepressant efficacy, particularly during the initial period when adolescents are most vulnerable to the confounding effects of SSRI treatment

It promotes the formation of plaques in the arteries (aka atherosclerosis), which can restrict blood flow

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