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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction

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Formed by tightly apposed endothelial cells supported by pericytes and astrocytic end-feet, the BBB restricts the entry of most small molecules, biologics, and nearly all gene-editing constructs [139]