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The CRM 13180 PDX model was provided by the laboratory of Dr Judith Leopold (University of Michigan) 61

Clinical evidence shows that GLP1R agonists not only improve glycemic control but also exert beneficial effects on body weight and the cardiovascular system, as confirmed in large-scale trials of agents such as Liraglutide (Marso et al., 2016), Dulaglutide (Lincoff et al., 2023)

However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics

Related work showed context-appropriate angiogenesis during muscle/tendon healing, with VEGF-linked markers in vivo (Brcic 2009)