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Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

Its not just about some metabolite levels going up and others going down

Bez-Flores ME, Troncoso-Rojas R, Osuna MAI, Domnguez MR, Pryor B, Tiznado-Hernndez ME (2011) Differentially expressed cDNAs in Alternaria alternata treated with 2-propenyl isothiocyanate