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Evidence: Green tea consumption is associated with lower serum folate in pregnant women Animal studies show neurodevelopmental effects from high-dose green tea Some studies report increased neural tube defect risk with daily tea consumption Who should avoid: Pregnant women (especially during the periconceptional period) Children with neurological or developmental issues Anyone with diagnosed cerebral folate deficiency Why Standard Treatment Falls Short The standard approach focuses almost entirely on prescription Leucovorin (folinic acid)typically 5-50 mg daily

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k , PDK1-silenced HCT116 were re-expressed with PDK1 WT or K163R mutant, and cells were subjected to in vitro PIP3 binding assay