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(A) Venn diagrams of the common DEGs among the two datasets and ferroptosis-related and autophagy-related genes (B) GO enrichment analysis and KEGG pathway analysis of co-DEGs (C) Expression levels of the five co-DEGs in GSE14668 (D) Expression levels of the five co-DEGs in GSE96851

Early case series and open-label studies support feasibility and biological plausibility, whereas randomized trials show mixed clinical signals, highlighting donor-dependent effects, protocol heterogeneity (preconditioning, route, dose/frequency), and the need for engraftment-aware endpoints [252,253,254,255]

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Injecting NAD is a key part of treatment