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Notably, although SLC25A40 is poorly characterized, emerging evidence links it, and its close paralog SLC25A39, to several disease states associated with mitochondrial dysfunction and oxidative stress

Defects in Glutathione Synthesis Glutathione is actively synthesized in RBC and has an intracellular half-life of only 4 days, in part due to cellular efflux of GSSG

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Considering the structure of 2-AB, we hypothesized that 2-AB is generated by an amino group transfer reaction to 2-OBA by amino transfer enzymes, such as aspartate aminotransferase (AST)