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It should be noted that an NADH-bound Mt DHDPR structure showed a partially closed conformation, with the authors speculating that this unexpected closed structure might represent a snapshot of the equilibrium state between open and closed forms awaiting further substrate binding, and that subsequent substrate binding might induce the fully closed conformation 21

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Tirzepatide is FDAapproved for specific indications, including type 2 diabetes and, at certain doses and brand names, chronic weight management in adults with defined BMI criteria plus at least one weight-related condition, when combined with lifestyle change