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Gut microbiota composition and relapse risk in pediatric MS: a pilot study

The direction of correlation between in vitro and in vivo findings appears broadly consistent across the body of evidence reviewed here: smaller PET NPs tend to have lower thresholds for biological effects, higher reactivity, more efficient biodistribution, and mechanisms of action more often driven by oxidative or genotoxic stress

Gut microbiota plays a pivotal role in metabolic activities, including dietary fiber fermentation, SCFA production, and regulation of gut permeability ( Figure 1 ) [51-53]