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The Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) model (Supplementary Figure S4) was used to identify differential metabolites among the three comparison groups

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They contain over 4,000 chemicals over 50 of which are known to be toxic in nature: the carbon monoxide also found in car exhaust fumes, butane found in lighter fluid, and arsenic, ammonia, and methanol found in rocket fuel, for example

[41] Flavored e-liquids form a major part of the appeal for using e-cigarettes, [42] especially for youth, for whom flavoring is cited as a major reason for using e-cigarettes