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Dihexa, a Small Molecule Angiotensin IV Analog, Reduces Age-Related Hearing Loss and Memory loss in Senescence-Accelerated Mouse Prone 8 Mice

Figure 2 Figure 3 GHR Structure and Activation Mechanism The crystal structure of GH bound to the GHR ECD showed that one GH molecule bound two GHR molecules ( via its site 2 interactions ( 104 and tryptophan 169 contributed significantly to site 1 interactions

8, 9, 10, 11 Oxidative stress occurs as the result of an accumulation of free radicals generated by normal metabolism and various environmental exposures to elicit cellular dysfunction

FGF21 is a pivotal regulator of metabolism, particularly in lipid and glucose pathways, and has been implicated in various mitochondrial disorders