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Following enucleation, the newly formed reticulocytes known as R1 reticulocytes are larger in comparison to mature erythrocytes and still contain residual organelles

However, research protocols often compare systemic (subcutaneous) administration with localized administration to determine if one is more effective for a specific injury model.

Indeed, translocation of Enterococcus gallinarum and Lactobacillus reuteri into various organs has been independently implicated in different mouse models of lupus (120, 121)